Triple X Syndrome – Symptoms, Pictures, Treatment, Life Expectancy

What is Triple X Syndrome?

Triple X Syndrome is also known as triplo-X, XXX syndrome, 47, XXX aneuploidy or Trisomy X and it is mainly due to an extra x- chromosome, which is an abnormal thing. Chromosomes are described to have a rod like kind of structure and are normally present in the cellular nucleus found in the person’s body.

It is where the genetic information is stored. Females are usually the only ones affected by this kind of disease syndrome. It is usually the result of the formation of the father’s sperm cell or the mother’s egg cell. It is caused by an error upon the embryo’s developmental stage. It is a rare genetic problem occurrence, which occurs in approximately 1 in every 1,000 of the female population. It is not easily diagnosed until reaching later in life.

Triple X Syndrome

Triple X Syndrome Symptoms and Signs

Female persons, who have been diagnosed with triple x syndrome, manifest the following signs and signs and symptoms:

  • Tall stature
  • Epicanthal fold or to vertical skin folds that may cover the eyes’ inner corners
  • Weak muscle tone
  • Delayed development of motor skills such as language and speech
  • Learning difficulties like dyslexia
  • Proportionately smaller head size or microcephaly
  • Introvert
  • Enamel Hypoplasia
  • Kyphosis
  • Small mandible
  • Low weight in comparison with their height
  • Lordosis
  • Mental retardation
  • Ovarian failure
  • Posteriorly rotated ears
  • Weak muscle tone
  • Menstrual irregularities
  • Having difficulty with interpersonal relationships
  • Infertility
  • Increased width between the persons eyes
  • The signs and symptoms mentioned above, varies from one person to another.
Triple X Syndrome symptoms

Triple X Syndrome Causes & Risk Factors

The genes are a basic part of the person’s whole existence, it is the one who decides its environmental behavior, how it survives and what the entire human is like. It will decide your physical features, your disease, your passions, and your gender. The genes are found in the DNA which is also called as the human chromosomes.

Normally, a person has 23 chromosomal pair or otherwise known as the sex chromosomes which will have the final say of what the person gender would be. Female babies usually have XX chromosome pair while Male babies have XY chromosome pairs. Both babies’ mother and the father contribute to the chromosomal pair and to their gender. The father can contribute the X or Y chromosome while the mother can only contribute the X chromosome. Babies or individual persons who have the triple x syndrome it may be due to:

  1. Mosaic form of triple x syndrome or there is an error in the embryo development. The error happens after the egg and the sperm is fertilized and before the development of the embryo.
  2. Nondisjunction or either the mother’s egg or the father’s sperm was not properly formed. It occurs in the sperm cell or egg cell production, wherein there is a cellular division error which occurs randomly.

One must take note that this kind of disease syndrome is not due to an inherited condition. It happens in the rarest occurrence. And it only happens with females. As mentioned, another name for this disease syndrome is 47, XXX syndrome due to the fact that the person has an extra X chromosome which resulted to the 47 chromosomes, which should be normally 46 chromosomes.

Triple X Syndrome Diagnosis

The triple x syndrome is usually diagnosed before the delivery of the baby and it is dune through:

  • CVS or Chorionic Villus Sampling – It is a diagnostic test that is done between the 8th and 10th week of the pregnancy period. What happens in this diagnostic test is that the baby’s tissue is taken from his or her placenta’s villi and will be examined further to test for either positivity of this kind of disease syndrome.
  • Amniocentesis – What happens here is that the amniotic fluid, where the baby, embryo or fetus floats, is collected and further examined.
  • Blood Test – This is done if the physician notices, upon physical assessment, physical developmental delays.
  • Genetic testing called Karyotyping – This is done to detect if really the female person has the extra X chromosome.

Triple X Syndrome Treatment

The treatment, which is usually based on the person’s symptoms, with female persons that have the triple x syndrome, will depend on the needs of the female person such as:

  • Physical therapy
  • Developmental therapy
  • Occupational therapy
  • Speech therapy
  • Psychological therapy or counseling
  • Supportive therapy

Triple X Syndrome Prognosis

The prognosis of persons diagnosed with triple x syndrome is good if they have parents who support them and love them unconditionally. In addition to that, compared to other genetic conditions or problems, the triple x syndrome is a manageable disease condition which is why the person has a good prognosis.

They have normal life expectancy. They often have to undergo speech therapy or acquire additional help from professional health workers to help them complete their academic stages. If some female are living as normal as possible wherein they are able to have their own families, they marry and some join the work force, still some females who have this disease syndrome have difficulty dealing with other persons.

Triple X Syndrome Complications

Female who were diagnosed with triple x syndrome leads to learning difficulties and delayed development which will lead to numerous issues such as stress, academic problems, poor socialization which leads to social isolation. Other complications include:

  • Seizure – Girls of female babies with this syndrome are typical to develop seizure disorder.
  • Kidney abnormalities – Females having this syndrome may have one kidney or abnormal development of their kidneys.
  • Premature ovarian failure or abnormalities in the ovaries – The female babies or women who have this disease syndrome may experience that their ovaries have halted working before menopausal stage which leads to the decrease hormonal production and ovulation proper doesn’t occur anymore which can cause infertility. Also, some of the women having this disease syndrome have malformation of their ovaries.

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20 thoughts on “Triple X Syndrome – Symptoms, Pictures, Treatment, Life Expectancy

  • 16/08/2013 at 2:54 PM

    I am a mother of xxx chromosomes I am looking for a treatment for my daughter she has poor academic results how could I help her thank you

    • 22/02/2015 at 9:33 AM

      I have triple X syndrome and honestly there is no treatment you simply have to embrace all the things that come along with it and target them individually. Like poor academic success for example. Treat her as an any other child struggling with school.

  • 24/02/2014 at 10:55 PM

    I have triple xxx syndrome and ive had speech therspy when i was younger and i have mild epilepsy and learning difficultes and autism and i am tall in height but other then that i think to myself as normal even tho no other people im not x

  • 24/02/2014 at 11:01 PM

    What you can do is take your daughter to a speacil needs school and the school will help her also you should find other familys who have a child or person with this condition and they will share there experiences with you so you can feel like you have a support group in case your worried about anything hope this helps x 🙂

  • 08/06/2014 at 3:08 AM

    Hi, I am an assistant in kindergarten and I am looking after a girl with triple xxx syndrome. In Slovakia is this diagnose rary so even her mother doesn´t know what to do with her. She is 3 zears old – not talking, not potty trained, she is not able to sit still, just walking around a classroom and throwing toys on floor. Can you help me and let me know how to deal with her? I promised her mum to find some answers on the internet. What can I do to educate her? Thanks a lot.

    • 23/12/2014 at 1:53 AM

      My daughter was the same not talking, slow in development, did not give hugs. I had to wait for her to come to me , instead of me crowding her. And repetition, repetition with everything. Hygiene, social skills, academics below 67 cognition, I have found that she loved the movement of icons and the ds lite made stimulate move for her in fifth grade, maybe I should have tried that earlier. She didn’t have verbal, hands on, visional way of learning til then. She loves art very good at color and design, singing, music. She loves to bake. I had to focus on what she could do and learning R x helped with confidence, counseling and physical therapy with social skills has been all threw school so far. She tends to mimic others and very forward, she has had to be monitored during her 8,9, 10th year to keep her verbal thoughts from being a danger. Birth control earlier at 15. She is now 17 and half and has always had an independence about her, that I try not to take that from her. OH- I forgot for us she started out boyish, but we did ballet and cheer to move her towards the girlish ways. That may have been her own charter but it helped with her hips and slinky move. I used to tease her (swing those hips and think happy thoughts- she has a anger look about her most of the time.) Not one case is the same hope this helps. God Bless

  • 19/03/2016 at 9:17 PM

    My teenage daughter is triple-x and the manifestation is not really noticeable. She is tall, but not off the charts. Her hands and feet are small, but not something you notice right away. She is somewhat clumsy. She is average or better at school depending on the subject and her interest.

    She is very good at art and music and any kind of craft. She has mild anxiety, but incredibly good social skills.

  • 08/04/2016 at 10:52 AM

    My 22 year old daughter was diagnosed at 7. It’s been very challenging to be patient with everything. But now, unfortunately, she has been displaying very strong emotional problems for the past 3 months. I’ve never experienced anything like it. She’s 22 acting like 16. Slamming doors, banging on the wall. It’s really terrible. She has never had medication for Triple X but next Tuesday talking to the doc about it at her appt. She has an appt Sunday with a counselor which I’m hoping and praying will help with the situation. Any advice would be greatly appreciated.
    Thank you

    • 28/04/2016 at 4:21 PM

      Am 16 weeks pregnant. Unfortunately dna scan found my baby is 47 xxx. Confuse if should continue with the pregnancy. We tried 5 years before success with ivf. Any advise…

      • 26/05/2016 at 11:44 AM

        I am a 47xxx. I found out that I have this problem in my 44yo. I checked my chromosomes because I had multiple miscarriages. I was born in Europe, in a poor socialist country, where the last thing to do or to think about it is to check the chromosomes. As per my family I was a very good kid, I was first in class, I finished my master degree in Italy, Rome. I am speaking 4 languages, I am having friends, just one happy marriage but no children, maybe because my genetic abnormalities….who knows??? In my case I think that having 47xxx it’s a plus. So, give a chance. Give a chance to someone like me maybe. If you want to discuss more about it, my email is God be with you and with your baby. Good luck.

      • 27/06/2016 at 3:42 PM

        My daughter was diagnosed with xxx syndrome at 10 months old. She also has mild scoliosis. She has struggled at school but she is resilient, respectful, loving, energetic and to us perfect in every way. She is going for her black belt in rhee tae kwondo. She is crafty and in year 11 at school. You have a very special little one just waiting to stamp their beautiful mark on this sometimes ordinary world. Your child is destined for remarkable things just like our Denna. Lucky you. Xxx

      • 11/07/2016 at 8:50 AM

        My daughter is 18 yrs old & just diagnosed with triple x due to ovarian failure. Otherwise she is completely normal, we never had a clue. Honors student & is going to college with a good scholarship. Passed her AP Calculus exam with the highest possible score! Don’t terminate your pregnancy.

      • 23/09/2016 at 9:23 PM

        Hi there, just wondering if you continued with your pregnancy. I wish I had seen this page sooner, my baby has Triple xxx and she is fantastic!

    • 21/06/2016 at 2:01 AM

      Liz I have a 23 year old daughter with trisomy X. Academics, speech and social behavior have been her biggest issues but not all. It wasn’t discovered until the age of 16 after problems with anesthesia. Her violence got worse as she got older to the point of various calls to the police. We did counseling for years which somewhat helped but we ended up turning to medication. She is much better with the medication and there is no more violence and she is very happy. Through the support of our family she has survived her parents difficult divorce and she just graduated college. Keep the faith..

  • 28/04/2016 at 4:17 PM

    Am 16 weeks pregnant. Unfortunately dna scan found my baby is 47 xxx. Confuse if should continue with the pregnancy. We tried 5 years before success with ivf. Any advise…

    • 05/06/2016 at 10:15 AM

      Dear Eli,
      I hope you read carefully before you considered terminating your pregnancy….. Im not sure what type of DNA scan you had but if you read the info out there most are not 100% accurate and also there is not much info on triple x out there but most of the information and personal testimonys have put me at ease… my opinion It is worth taking a chance with your precious little life that you have been patiently awaiting…. In most cases there are little to no symptoms…… You have to remember that. i have been given the same news as you about my baby girl in vitro …. I have 4 sons and the initial news of having a baby girl sent me over the moon….. Im 40yrs old and was supposedly finished having babies until this little surprise….. And yesterday to my dismay my OB called me to share with me the results of my NIPT scan….. And i have been questioning this pregnancy as you have …. But After reading as much as i can i am starting to realize that it is way worth the chance…. The chance of having a perfectly fine baby girl is much greater than having a child that displays even the most severe symptoms of this syndrome and even at that we should still count ourselves blessed…. Especially after reading the personal testimonys of the woman that actually have the genetic anomaly themselves, those with and without symptoms…good luck with your decision…. No judgement here…..

      • 26/06/2016 at 8:41 AM

        You said it best! I’m one of those with this syndrome and literally never knew. I’ve always been smart, look normal, etc. only found out because I had several miscarriages and had genetic testing. I have 3 boys that are normal. 2 are even extremely smart. DO NOT TERMINATE!

    • 26/06/2016 at 8:26 AM

      Keep going, I have it, have absolutely no issues, look normal and have always been smart. Only reason I found out I had it was I got genetic testing due to miscarriages. But I have 3 healthy boys and am completely normal. That’s why it makes me really mad that anyone would consider abortion with my “syndrome”. I think most people with this don’t even know it. Maybe there are extreme cases with issues, but probably most do not. If you really want a child, don’t kill him/her because you don’t think they’ll be “perfect”.

  • 11/07/2016 at 7:00 AM

    I have a twenty one year old with this. I found out while pregnant ( I was 40). She’s 5’9 and beautiful. Unfortunately I divorced her dad at age three which might have been a trigger because I believe a stable and loving environment is key. Her father does not believe any of her issues are a product of having XXX syndrome which gave me little support. From age 7 forward there have been issues with behavior. We’ve gone through a lot of counseling but she will not communicate with them. She has always had issues with reading comprehension but excels in math and science. Social skills have been a challenge for her because she’s immature for her age versus her same age peers. Most of her friends are a few years younger. Under stress she gets very combative. Slamming doors throwing things. We’ve tried meds but she will not take on a regular basis. i think each child is different with this as with all children are different. You deal with it the best you can and hope for the best and continue to love them.


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