Lennox Gastaut Syndrome – Life Expectancy, Symptoms, Treatment

What is Lennox Gastaut Syndrome?

A seizure is considered to be a short period of bursting abnormal electrical activity in a person’s brain. When it recurs over and over, it is medically termed, epilepsy, which is a seizure disorder. The severe form of epilepsy is recognized as Lennox-Gastaut syndrome. It usually starts before a child turns 4-years-old. It’s characteristics are multiple types of epileptic seizures.

Lennox Gastaut Syndrome Pics

Lennox Gastaut Syndrome

Lennox Gastaut Syndrome Symptoms and Signs

The patients diagnosed with Lennox Gastaut syndrome will experience the following signs and symptoms:

Multiple seizure types

Seizures that are experienced may vary between the following:

Atonic seizures

Considered as the “drop attack”  seizure. During this kind of seizure, the child suddenly falls to the ground, which may be mistaken as poor balance or tripping up. It usually happens many times in a day.

Absences seizures

An atypical seizure that last from 10 seconds to several minutes. The child usually stares blankly, appears vacant, and manifests rapid blinking or head nodding.

Status epilepticus

It can be either convulsive or non convulsive type of epilepticus. It can be a life-threatening seizure, lasting for about 30 minutes or longer with a series of seizures.  The person does not regain consciousness in between each seizure.

Tonic seizures

Another common seizure is a tonic seizure. It occurs when the child is asleep at night. It disturbs their sleep but doesn’t wake the child. These seizures also go undetected because of their brevity.

Tonic clonic seizures

The combination of tonic and clonic seizure. In the tonic phase, the child’s body goes stiff, while in the clonic phase, the seizure begins.

Complex partial seizures

A form of a partial seizure. It is when the child loses awareness of the seizure activity. He or she may perform actions such as walking, riding a bike, or talking and may have physical, thought, and sensory disturbances.

Myoclonic seizures

Is a seizure that has a jerking (Myoclonic) characteristic of the muscles without the loss of consciousness.

  1. Cognitive impairment, which is usually a delay in the development of the cognitive aspect and is seen over time.

Lennox Gastaut Syndrome Causes & Risk Factors

70% of children who have the diagnosis of Lennox-Gastaut syndrome are symptomatic and the remaining 30% are cryptogenic or have no underlying etiology. Some of the children reported to have one of the types, have a family background of epilepsy. However, such a syndrome doesn’t have direct evidence that it can be inherited. Those who have symptomatic Lennox –Gastaut syndrome have the following possible causative factors:

  1. Brain malformations like cortical dysplasia or tuberous sclerosis
  2. CNS or central nervous system infection
  3. Metabolic or degenerative nervous system disorders
  4. Brain injury before, during, or upon birth

Lennox Gastaut Syndrome Diagnosis

In diagnosing the Lennox Gastaut Syndrome, the physician performs the following actions and confirmative diagnostic exams:

  1. Medical History pertaining to previous seizure or family history of seizure episodes
  2. Physical Assessment, such as injury that has been caused by a seizure
  3. Neurological examination is also assessed to determine if the neurological aspect is already affected.
  4. EEG or Electroencephalography, which records the brain’s electrical activity. It is an important diagnostic exam that shows either normal or abnormal patterns of brain activity. For patients positive with this syndrome, it will appear on the monitor as continuous spike waves whenever a person is in a slow sleep state and it also shows fast rhythms in a diffuse slow background.
  5. Other testing, such as urine tests or blood specimens, or an test on cerebrospinal fluid through lumbar puncture, may be done when children have no apparent causative factor that causes the seizure. This is done to detect any underlying genetic or metabolic cause.

Lennox Gastaut Syndrome Treatment

With regards to the treatment of Lennox Gastaut Syndrome, the following treatment therapies are usually prescribed:

  1. Pharmacological medications such as iamotrigine, ethosuximide, sodium valproate, clobazam and phenytoin. Such medication will not cure the disease, but will only manage the seizures.
  2. Ketogenic diet, which is a low carbohydrate and special high fat diet.  A nutritionist and physicians will prescribe to help in seizure management. It increases the ketones in the body, a popular diet for the epileptic persons.
  3. Surgical Procedure such as vagus nerve stimulation and corpus callosotomy may be considered.

Lennox Gastaut Syndrome Prognosis

The prognosis for patients with Lennox Gastaut Syndrome differs from one person to another. Since there is no specific treatment for this kind of syndrome, the seizure will continue throughout life.

The long term prognosis of a person with this syndrome with regards to intellectual development and seizure control is poor. Their IQ will deteriorate as time goes by and will need assistance from other people as they get older.

They will also have behavioral problems brought about by the antiepileptic drug’s side effects, seizures, and brain dysfunction. Some children will outgrow seizures upon their teenage years, while others will still continue to experience seizure episodes until they reach adulthood. If this occurs, they will be dependent on others. Still, some will develop infections, which will lead to a shorter life expectancy and will lead to an even poorer prognosis.

Lennox Gastaut Syndrome Complications

The complications associated with this kind of syndrome include:

  1. Injuries from seizure
  2. Renal, cardiac, or metabolic complications resulting from the Ketogenic diet
  3. Disconnection syndrome resulting from corpus callosotomy surgical procedure
  4. Language disorders brought about by the corpus callosotomy procedure
  5. Motor dysfunction as a result of the corpus callosotomy procedure
  6. Neurophysical impairment associated with the corpus callosotomy procedure
  7. Mental retardation as time progresses
  8. Death

Lennox Gastaut Syndrome Prevention

The only preventive action is to prevent epilepic seizures from occurring, specifically the ones that are known to occur with Lennox Gastaut syndrome. You can only prevent seizures from occurring by taking the prescribed medications mentioned above and following a Ketogenic diet or perhaps undergoing a surgical procedure, such as one of the ones mentioned above.

Proofreaded for grammar on 15/10/2012.

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12 Responses to “Lennox Gastaut Syndrome – Life Expectancy, Symptoms, Treatment”

  • william ryan says:

    i need info on LGS for my sons teachers at school if you know how i can get info through the mail please let me know and GOD BLESS

  • Marilyn J. Medley says:

    I began volunteering with a young man with LGS. He was 16 years old at that time. He turned 32 years old this past November. For those of you that have young children and would like someone to ask questions, please feel to email me. I will be glad to share my experiences with you.

    • Peggy Chandler says:

      Hi I’ve had the pleasure of providing medical care in a school setting for four years for a young man with LGS. I’m always looking for ways to stimulate his environment with creative ideas especially at school since I manage his course schedule as well. I would love any ideas or experiences.

      Thank you,
      Peggy Chandler

    • Jody says:

      I have a 13 year old daughter we believe to have LGS, also seeing neurologist tomorrow to diagnosis of LGS. Since being diagnosed with epilepsy in 2007 we have been unable to control clusters of seizures also new seizure development. She has always had every symptom of LGS. Would love to talk with you. Thanks Jody

  • amanda says:

    Hi my name is Amanda and I have a 3 yr old son that got diagnosed with lgs. I’m getting no answers and he’s been on the vent for two months now I don’t understand what’s going on. I know its not food but nobody is listening to me!!! Please contact me aspencer0720@gmail.com or 512-876-4279 text or,call

    • Jan says:

      I sent you an email a few minutes ago and I’m posting this here so if you would like to write to me you can.

  • cecilia garibay bustos says:

    Hy mi name is cecy from mexico df and ay have a son that haves sindrome de lenox and atrofia cortcal fronto temporal severa, he cant see and dosents speks and walks and talks and he hasent have a seizure since a month and thas a miracle y have beeng givin him the juice of noni its a fruit if you have more information or ai need help for mi son we live in very poor situacion thak you if you reed this the name of mi son is daniel hi is 3yers.

  • Lisa L says:

    My son is turning 17 and he was diagnosed as an infant.I don’t recall any of his doctors mention the diagnosis of LGS until a few years ago.

  • ellen lord says:

    I am the mother of a son who had lgs. he developed this at 2 years old it was the most heartbreaking time of our life,but ada was a happy little boy who loved spongebob and life, he was very mischeivious and had so many people that loved him, I fought the school system and tried to educate the people around him about the disease,onw morning when I went in to wake himup he had passed away he was 9 years old.we miss him so much and as a tribute to him I donated his eyes and heart stem to another child I would be interested in talking to anyone who has gone through this thankyou

  • Carolyn Catalano says:

    My son is 39 yrs old. His seizures began at 9 months old. We heard LGS at 12 yrs old when he was at Blue Ridge Hospital for consultation with Fritz Driefuss… Then we heard nothing again until the last few years.. Jason is a beautiful soul. He tries hard but has become a shell of who he was. He lives with me. I have built my life around him.. bringing my buisness in and having respite help when I work. I have always kept Jason as active as I can.. enrolled in special needs activities from Special Olympics while he could do it… to Acting and Glee club.. I think the more involved you keep your people the better for everyone. He loves his activities and his home.. we also have a wonderful companion dog that loves to sit with him.

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